Czech scientists develop new method to better target cancer drugs and supress side effects

A new method developed by Czech scientists could eliminate the unpleasant side effects of cancer therapy. Experts from the Academy of Sciences have come up with a new chemical reaction, based on so-called fluorescent tagging, that allows them to better target drugs to specific places in the human body.

The new chemical reaction developed by scientists from the Institute of Organic Chemistry and Biochemistry at the Academy of Sciences promises significant progress in targeting drugs to selected locations in the body, such as a cancerous tumour.

Thanks to this reaction, called triazinium ligation, it is possible to modify biomolecules, such as proteins or peptides, so that they reach, along with the drug, the desired location. The method also allows scientists to monitor the movement of the drug in the human body, says head of the research team, Milan Vrábel.

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Authors: Ruth Fraňková, Eva Kézrová